Evidence map›Paper›PMID 42850284›Full record

ArticleNature communications2026

Recognition and mechanism of M. tuberculosis cell wall galactan transport.

Chuancun Wei, Katherine A Abrahams, Violetta Krisilia, Jian Li, Sudagar S Gurcha, Eveline Derr, Milena Hänisch, Rainer Kalscheuer, Gurdyal S Besra, Zihe Rao and 1 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chuancun Wei *Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0008-1387-4950
Katherine A Abrahams *Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK.ORCID http://orcid.org/0000-0002-0769-3423
Violetta Krisilia *Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical Biology and Biotechnology, Düsseldorf, Germany.ORCID http://orcid.org/0009-0000-3256-8627
Jian LiShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Sudagar S GurchaInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK.
Eveline DerrHeinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical Biology and Biotechnology, Düsseldorf, Germany.ORCID http://orcid.org/0009-0001-6586-9204
Milena HänischHeinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical Biology and Biotechnology, Düsseldorf, Germany.
Rainer KalscheuerHeinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical Biology and Biotechnology, Düsseldorf, Germany. rainer.kalscheuer@hhu.de.ORCID http://orcid.org/0000-0002-3378-2067
Gurdyal S BesraInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. g.besra@bham.ac.uk.ORCID http://orcid.org/0000-0002-5605-0395
Zihe RaoShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-9866-2384
Lu ZhangShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhanglu1@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-4626-5990

Funding

National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32394010National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32394011RCUK | Medical Research Council (MRC) MR/S000542/1 and MR/R001154/1
6 · The paper itself

Abstract

Mycobacterial-derived lipid-linked galactan (LLG) is an essential component of the Mycobacterial tuberculosis (Mtb) cell wall core arabinogalactan (AG), a well-established virulence factor and target of anti-tubercular drugs. Cross-membrane translocation of LLG is energetically unfavorable and is therefore catalyzed by WzmWzt, a prominent member of the polysaccharide ABC transporter sub-family. Here we present cryo-EM structures of WzmWzt

Indexed as

ATP-Binding Cassette TransportersBacterial ProteinsCell WallGalactansMycobacterium tuberculosisAdenosine TriphosphateBiological TransportCryoelectron MicroscopyAdenosine TriphosphatearabinogalactanATP-Binding Cassette TransportersBacterial ProteinsGalactans

Identifiers

PMID42850284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.