In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Dejin Xie *Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-4879-4981 Xikai Yu *Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0001-5832-2684 Wenwen ZhangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0009-0001-2519-7618 Xianjin QinShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-4610-4844 Qi ZhouShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0009-0001-3270-3873 Fengjiao WangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0009-0007-5347-8875 Xuezhu LiaoShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-4599-5809 Ran DuShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-6647-0780 Li WangShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. wangli03@caas.cn.ORCID http://orcid.org/0000-0003-2068-7535 Wei LiShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. liwei11@caas.cn.ORCID http://orcid.org/0000-0002-8670-584X Funding
National Natural Science Foundation of China (National Science Foundation of China) 32170264Shenzhen Science and Technology Innovation Commission GJHZ20240218114715030
6 · The paper itselfAbstract
Isofraxidin, a characteristic coumarin extracted from the root of Sarcandra glabra, prevents human hepatoma cell invasion, while its biosynthesis remains elusive. Here, we construct a 4.23-Gb chromosome-level genome of S. glabra. We find that its intergenic and genic regions are profoundly longer than those of other angiosperms. Among the root-enriched O-methyltransferase candidates, SgOMT3 produces comparable amounts of isofraxidin and the byproduct fraxidin from fraxetin, while SgOMT5 only produces fraxidin. SgOMT3 and SgOMT5 are dispersed duplication genes, and site-directed mutagenesis reveals that Leu127 in SgOMT3 and Val292 in SgOMT5 are the key residues for isofraxidin and fraxidin biosynthesis, respectively. SgOMT3 orthologs from eudicot species preferentially produce more isofraxidin than fraxidin. The molecular docking and site-directed mutagenesis reveal that a Leu-to-Ile substitution at position 307 alters the regioselectivity of SgOMT3, shifting the conversion predominantly toward isofraxidin. These findings accelerate germplasm improvement of S. glabra and provide evidence for isofraxidin biosynthesis in chassis.
Indexed as
CoumarinsGenome, PlantMagnoliopsidaMethyltransferasesPlant ProteinsAmino Acid SequenceMolecular Docking SimulationMutagenesis, Site-DirectedPhylogenyCoumarinsMethyltransferasesPlant Proteins
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