Evidence map›Paper›PMID 42850276›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Comparison of growth and morbidity outcomes in preterm infants using two different intravenous lipid emulsions.

Alexyss Guy, Austin Han, Diana Kwiatkowski, Anna C Felmer, Christina Gerber, Rachel H Lee, Amrita Nayak, Rebecca Goodman, Dave Gothard, Rita M Ryan and 2 more

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexyss GuyDepartment of Pharmacy, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
Austin HanDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, USA.
Diana KwiatkowskiDepartment of Pharmacy, Mount Sinai Hospital, New York, NY, USA.
Anna C FelmerDepartment of Pharmacy, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.ORCID http://orcid.org/0009-0002-8309-5692
Christina GerberDepartment of Pharmacy, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Rachel H LeeDepartment of Pediatrics, Division of Neonatology, NYU Langone Hospital - Long Island, NYU Grossman Long Island School of Medicine, Mineola, NY, USA.
Amrita NayakDepartment of Pediatrics, Division of Neonatology, NYU Langone Hospital - Long Island, NYU Grossman Long Island School of Medicine, Mineola, NY, USA.
Rebecca GoodmanDepartment of Pediatrics, Division of Neonatology, NYU Langone Hospital - Long Island, NYU Grossman Long Island School of Medicine, Mineola, NY, USA.
Dave GothardBiostats Inc, East Canton, OH, USA.
Rita M RyanDivision of Neonatology, Department of Pediatrics, UH Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA. rita.ryan@uhhospitals.org.ORCID http://orcid.org/0000-0002-4588-3412
Jaime MaraschDepartment of Pharmacy, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4357-0308
Zeyar T HtunDepartment of Pediatrics, Division of Neonatology, NYU Langone Hospital - Long Island, NYU Grossman Long Island School of Medicine, Mineola, NY, USA.ORCID http://orcid.org/0000-0002-0768-1887

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare growth z-scores and prematurity-related comorbidities for preterm infants receiving Soybean Oil-Intravenous Lipid Emulsion (SO-ILE) versus Soybean + Medium-chain triglycerides + Olive + Fish oil ILE (SMOF-ILE). STUDY

designA multicenter, retrospective cohort study of 347 preterm infants <32 weeks' gestational age with birth weight ≤1500 grams who received SO-ILE or SMOF-ILE for at least seven consecutive days.

resultsSO-ILE group (n = 179) demonstrated significantly improved growth for length (p ≤ 0.001) and head circumference z-scores (p = 0.015) at 36 weeks' postmenstrual age and significantly worse growth for weight z-scores at 1 month (p = 0.017) compared to the SMOF-ILE group (n = 168). SO-ILE group had significantly lower rates of bronchopulmonary dysplasia (BPD) (p < 0.001) and urinary tract infections (UTI) (p = 0.045).

conclusionIn this population, SO-ILE had better outcomes for growth, BPD, and UTI compared to SMOF-ILE. Therefore, SO-ILE remains a reasonable lipid emulsion for preterm infants until more evidence is available.

Identifiers

PMID42850276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.