SynthesisNature communications2026
Refining biopsy strategies stratified by PI-RADS score in men: a systematic review and network meta-analysis.
Synthesis in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
Abstract
Prostate cancer is the second most common cancer in men globally. Advances in diagnostic techniques, particularly multiparametric magnetic resonance imaging and the Prostate Imaging Reporting and Data System, have enhanced detection precision. However, optimal biopsy strategies for lesions with Prostate Imaging Reporting and Data System scores of 3-5 remain uncertain. Here we show that saturation targeted biopsy and ipsilateral systematic biopsy combined with targeted biopsy achieve comparable detection rates of clinically significant prostate cancer to the combined systematic and targeted biopsy approach for Prostate Imaging Reporting and Data System 3-5 lesions, while reducing unnecessary biopsies. Targeted biopsy alone remains insufficient, and omitting systematic biopsy in Prostate Imaging Reporting and Data System 5 lesions is not supported. These findings support tailored biopsy strategies based on Prostate Imaging Reporting and Data System scores, optimizing resource allocation and minimizing overdiagnosis. Further validation in larger cohorts with standardized protocols is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.