Evidence map›Paper›PMID 42850024›Full record

Trial reportBMJ open diabetes research & care2026

Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial.

Hana Kahleova, Kitt Petersen, Gerald I Shulman, Tatiana Znayenko-Miller, Sylvie Dufour, Haley Brennan, Cristina Maracine, Andrea Tura, Richard Holubkov, Neal D Barnard

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open diabetes research & care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06106035 (The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06106035 nacompletednot on this map

The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2024 to 2025Enrolled26ConditionsDiabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in ObeseArmslow-fat vegan diet
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hana KahleovaClinical Research, Physicians Committee for Responsible Medicine, Washington, District of Columbia, USA hana.kahleova@gmail.com.ORCID http://orcid.org/0000-0003-0491-3993
Kitt PetersenInternal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Gerald I ShulmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Tatiana Znayenko-MillerClinical Research, Physicians Committee for Responsible Medicine, Washington, District of Columbia, USA.
Sylvie DufourDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Haley BrennanClinical Research, Physicians Committee for Responsible Medicine, Washington, District of Columbia, USA.
Cristina MaracineClinical Research, Physicians Committee for Responsible Medicine, Washington, District of Columbia, USA.
Andrea TuraMetabolic Unit, ISIB-CNR, Padova, Italy.
Richard HolubkovSchool of Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Neal D BarnardClinical Research, Physicians Committee for Responsible Medicine, Washington, District of Columbia, USA.

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Targeting hepatic mitochondrial oxidation to treat NAFLD, NASH and type 2 diabetesR01DK135645 · NIDDK · YALE UNIVERSITY · PI KITT F PETERSEN, GERALD I SHULMAN · 2024 to 2026
$2.1M
NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK135645
6 · The paper itself

Abstract

objectiveThe aim of this study was to explore the effects of a low-fat plant-based diet on hepatocellular and intramyocellular lipids, advanced glycation end products (AGEs), insulin resistance, and beta-cell function in adults with type 2 diabetes. RESEARCH DESIGN AND

methodsParticipants (n=25) were asked to follow a low-fat vegan diet for 16 weeks. Dual X-ray absorptiometry was used to measure body composition. Hepatocellular and intramyocellular lipids were quantified by

resultsMean body weight decreased by 6.0 kg (95% CI -7.0 to -5.1; p<0.001), a 6.6% (95% CI -7.5 to -5.8) decrease relative to baseline. This was largely due to the reduction in fat mass (-4.2 kg, 95% CI -5.7 to -2.7; p<0.001). Visceral fat volume decreased by 290 cm

conclusionsOn an ad libitum low-fat plant-based (vegan) dietary intervention, the participants with type 2 diabetes experienced reductions in ectopic fat, particularly visceral and hepatocellular fat, improvements in insulin sensitivity, reductions in AGEs, and improvements in beta-cell function. TRIAL REGISTRATION NUMBER: NCT06106035.

Indexed as

Diabetes Mellitus, Type 2Diet, Fat-RestrictedDiet, VeganInsulin ResistanceInsulin-Secreting CellsLipidsAdultBlood GlucoseBody CompositionFemaleFollow-Up StudiesGlycation End Products, AdvancedHumansLiverMaleMiddle AgedBlood GlucoseGlycation End Products, AdvancedLipidsDiabetes Mellitus, Type 2Non-alcoholic Fatty Liver DiseaseNutritional Sciences

Identifiers

PMID42850024
PMCPMC13656109

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.