Evidence map›Paper›PMID 42848840›Full record

ArticlePLoS biology2026

Distinct millisecond-scale click-train patterns evoke discriminable behavioral and neural responses in humans and rats.

Yuying Zhai, Peirun Song, Ana Belén Lao-Rodríguez, Xinyu Du, Haoxuan Xu, Hangting Ye, Xuehui Bao, Ishrat Mehmood, Nayaab Shahir Pandit, Cheng Chang and 9 more

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Article in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Yuying ZhaiDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Peirun SongDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Ana Belén Lao-RodríguezCognitive and Auditory Neuroscience Laboratory (Lab 1), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.
Xinyu DuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Haoxuan XuCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Hangting YeDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xuehui BaoCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Ishrat MehmoodCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Nayaab Shahir PanditCollege of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
Cheng ChangDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhouyou DaiDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhiyi TuDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Pei ChenDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Tingting ZhangDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Lingling ZhangDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Xuan ZhaoDepartment of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
David Pérez-GonzálezCognitive and Auditory Neuroscience Laboratory (Lab 1), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.
Manuel S MalmiercaCognitive and Auditory Neuroscience Laboratory (Lab 1), Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain.ORCID https://orcid.org/0000-0003-0168-7572
Xiongjie YuDepartment of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0002-0040-2187

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural sounds are shaped by both spectral content and temporal patterning. Here we ask whether click trains with the same mean inter-click interval, but different millisecond-scale temporal patterns evoke distinct behavioral and neural responses. Human listeners discriminated several such click-train patterns, and human EEG revealed context-dependent deviance-related responses. Awake rats showed analogous cortical response differences at the ECoG level. Along the IC-MGB-A1 pathway, unit recordings revealed weak oddball/context sensitivity in IC, intermediate sensitivity in MGB, and stronger stimulus-specific adaptation in A1. Reversible inactivation of the auditory cortex reduced MGB sensitivity, indicating a contribution of corticothalamic feedback. Further A1 layer analyses showed stronger effects in supragranular than deep cortical layers. Together, these results show that distinct click-train temporal patterns are differentially represented across the auditory system, with stronger sensitivity emerging in higher auditory structures.

Indexed as

Auditory CortexAuditory PerceptionAcoustic StimulationAdultAnimalsAuditory PathwaysElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleRats

Identifiers

PMID42848840
PMCPMC13686464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.