Evidence map›Paper›PMID 42848444›Full record

ArticleeLife2026

Genome-wide synthetic lethality screen of Bam complex-associated genes in

Jack A Bryant, Kara A Staunton, Hannah M Doherty, Micheal B Alao, Xuyu Ma, Joanna Morcinek-Orlowska, Emily C A Goodall, Jessica Gray, Matthew Milner, Luke Kidger and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jack A Bryant *Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.ORCID https://orcid.org/0000-0002-7912-2144
Kara A Staunton *Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Hannah M DohertyInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Micheal B AlaoInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Xuyu MaInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Joanna Morcinek-OrlowskaDepartment of Biology, University of Gdańsk, Gdańsk, Poland.
Emily C A GoodallInstitute for Molecular Bioscience, University of Queensland, St. Lucia, Australia.
Jessica GrayInstitute for Molecular Bioscience, University of Queensland, St. Lucia, Australia.
Matthew MilnerInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Luke KidgerSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Charly D NeilsonSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Jeffrey A ColeInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Felicity de CoganSchool of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Timothy J KnowlesInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.
Monika GlinkowskaDepartment of Biology, University of Gdańsk, Gdańsk, Poland.
Danesh MoradigaravandLaboratory of Infectious Disease Epidemiology, Biomedical Sciences (BioMed) Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.ORCID https://orcid.org/0000-0001-6652-5617
Ian R HendersonInstitute for Molecular Bioscience, University of Queensland, St. Lucia, Australia.ORCID https://orcid.org/0000-0002-9954-4977
Manuel BanzhafInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, United Kingdom.ORCID https://orcid.org/0000-0002-4682-1037

Funding

Academy of Medical Sciences SBF005\1112Biotechnology and Biological Sciences Research Council BB/Y001265/1Horizon 2020 Framework Programme 10.3030/721484King Abdullah University of Science and Technology BAS/1/1108-01-01Narodowe Centrum Nauki UMO-2014/13/B/NZ2/01139Royal Society RGS\R2\242458UK Research and Innovation MR/V027204/1
6 · The paper itself

Abstract

Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding, and insertion of outer membrane proteins (OMPs). The

Indexed as

Bacterial Outer Membrane ProteinsEscherichia coliEscherichia coli ProteinsSynthetic Lethal MutationsGene Knockout TechniquesMolecular ChaperonesBacterial Outer Membrane ProteinsEscherichia coli ProteinsMolecular ChaperonesBam complexbiochemistrychemical biologyescherichia coliEscherichia coligeneticsgenomicsOMPTraDIS

Identifiers

PMID42848444
PMCPMC13649257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.