Evidence map›Paper›PMID 42848426›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Pyrrolysine supply and demand shapes the translational landscape in

Grace D Britt, Daniel R Utter, Yeonsoo Park, Victoria J Orphan, Rodney Tollerson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pyrrolysine supply and demand shapes the translational landscape inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Grace D BrittDepartment of Biological Sciences, Auburn University, Auburn, AL 36849.ORCID 0009-0002-9395-3603
Daniel R UtterDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-3322-7108
Yeonsoo ParkDivision of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-6205-4544
Victoria J OrphanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-5374-6178
Rodney TollersonDepartment of Biological Sciences, Auburn University, Auburn, AL 36849.ORCID 0000-0002-1906-4296

Funding

NSF (NSF) 2126631U.S. Department of Energy (DOE) DE-SC0022991
6 · The paper itself

Abstract

The amber stop codon (UAG) can encode for pyrrolysine (Pyl) or be read as a stop codon by methylamine-metabolizing organisms including methanogenic archaea. The fate of UAG is decided during the decoding step of translation by competition between the pyrrolysine-aminoacylated transfer RNA (Pyl-tRNA

Indexed as

LysineMethanosarcinaProtein BiosynthesisCodon, TerminatorGenetic CodeRibosome ProfilingRibosomesRNA, TransferCodon, TerminatorLysinepyrrolysineRNA, Transfergenetic code expansionMethanosarcina acetivoranspyrrolysineribosome pausingtRNA charging

Identifiers

PMID42848426
PMCPMC13663744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.