ArticleProceedings of the National Academy of Sciences of the United States of America2026
Transcriptional regulation and function of GPR18 in macrophage subtype specification.
Hebe Agustina Mena, Andreas Patsalos, Jake Altomare, Filippa Davidsson, Gergely Nagy, Wilhelm K Berger, Blenda Wong, Allison Rahtes, Gabrielle Fredman, Laszlo Nagy and 1 more
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In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Hebe Agustina Mena *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Andreas Patsalos *Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-9022-4985 Jake AltomareCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0009-0007-4332-5242 Filippa DavidssonCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Gergely NagyDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen H-4012, Hungary.
Wilhelm K BergerDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-0727-7064 Blenda WongCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Allison RahtesDepartment of Molecular and Cellular Immunology, Albany Medical College, Albany, NY 12208.
Gabrielle FredmanDepartment of Molecular and Cellular Immunology, Albany Medical College, Albany, NY 12208.
Laszlo NagyDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-6653-2155 Matthew SpiteCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-8868-3648 Funding
Role of Inflammation-Resolving Lipid Mediators In Ischemic RevascularizationR01HL106173 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SPITE, MATTHEW R · 2011 to 2023
$5.7MDHA-derived resolvin production andsignaling in tissue repair macrophages in metabolic diseaseR01DK124782 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI NAGY, LASZLO, SPITE, MATTHEW R · 2020 to 2023
$2.3MHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL106173HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK124782NHLBI NIH HHS R01 HL106173NIDDK NIH HHS R01 DK124782
6 · The paper itselfAbstract
Resolution of inflammation is mediated in part by agonists that engage immune cells to dampen inflammatory signaling, promote phagocytic functions, and facilitate tissue repair. G protein-coupled receptor 18 (GPR18) has emerged as an important proresolving receptor that is activated by endogenous mediators including Resolvin D2. However, very little is known about how GPR18 expression is controlled in immune cells, and its cell-autonomous roles during resolution of inflammation remain of interest. Here, we elucidated transcriptional and epigenetic regulation of
Indexed as
Gene Expression RegulationMacrophagesReceptors, G-Protein-CoupledTranscription, GeneticAnimalsCore Binding Factor Alpha 2 SubunitInflammationInterferon-gammaInterferon Regulatory Factor-8Interferon Regulatory FactorsMiceMice, Inbred C57BLNF-kappa BProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Signal TransductionCore Binding Factor Alpha 2 SubunitInterferon-gammaInterferon Regulatory Factor-8Interferon Regulatory FactorsNF-kappa BProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Receptors, G-Protein-CoupledRunx1 protein, mouseTrans-ActivatorsTranscription FactorsG protein–coupled receptorsmacrophagesresolution of inflammation
Identifiers
PMID42848422
PMCPMC13660429
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