Evidence map›Paper›PMID 42848420›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K

Trevor Docter, Ben Sorum, Baobin Li, Robert A Rietmeijer, Annan S I Cook, Abhay Kotecha, Stephen G Brohawn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Trevor Docter *Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Ben Sorum *Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0001-6742-1094
Baobin Li *Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0002-4560-4575
Robert A RietmeijerDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0002-3181-9452
Annan S I CookDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Abhay KotechaMaterials and Structural Analysis, Thermo Fisher Scientific, Eindhoven 5651 GG, The Netherlands.
Stephen G BrohawnDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0001-6768-3406

Funding

Structural basis for K2P channel gating and modulationR01GM145869 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROHAWN, STEPHEN GRAF · 2022 to 2025
$1.3M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM145869NIGMS NIH HHS R01 GM145869
6 · The paper itself

Abstract

TWIK-related acid-sensitive K+ channel 2 (TASK-2) is a pH sensing two-pore K

Indexed as

Anesthetics, LocalBupivacaineIon Channel GatingPotassium Channels, Tandem Pore DomainAnimalsCryoelectron MicroscopyHumansHydrogen-Ion ConcentrationModels, MolecularAnesthetics, LocalBupivacainePotassium Channels, Tandem Pore Domaincryo-EMK2P channellocal anestheticpH sensing

Identifiers

PMID42848420
PMCPMC13663809

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.