Evidence map›Paper›PMID 42848287›Full record

ArticleMedical oncology (Northwood, London, England)2026

A20 promotes OPN ubiquitination and degradation to inhibit cell growth and invasion in human hepatocellular carcinoma.

Xiangqian Zhang, Zhi Li, Jianyan Qin, Dandan Zhu, Shuhong Zhang, Ye Zhang, Ying Fu, Xiaojin Liu, Qigang Shao

Abstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiangqian Zhang *Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Zhi Li *Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Jianyan QinDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Dandan ZhuDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Shuhong ZhangDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Ye ZhangDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Ying FuDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xiaojin LiuDepartment of Plastic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. xiaojin_liu@csu.edu.cn.
Qigang ShaoDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. qgshao@csu.edu.cn.

Funding

the Natural Science Foundation of China 81502542the Natural Science Foundation of China 82474131the Natural Science Foundation of Hunan Province 2023JJ40939the Natural Science Foundation of Hunan Province 2024JJ5567the Natural Science Foundation of Hunan Province 2026JJ80998
6 · The paper itself

Abstract

Abnormal osteopontin (OPN) expression has been implicated in hepatocellular carcinoma (HCC) progression. In this study, we assessed the prognostic value and biological functions of OPN in HCC. We also identified that A20 interacts with OPN and promotes OPN ubiquitination and protein degradation through the ubiquitin-proteasome system. The reduction in OPN levels induced by A20 attenuates OPN-associated proliferative and migratory phenotypes in HCC cells. Notably, advanced HCC tissues exhibited elevated OPN levels, while A20 expression showed variable patterns in clinical samples. In the clinical cohort, high OPN expression was associated with poorer overall survival, while high A20 expression was also unexpectedly associated with unfavorable prognosis. Combined analysis of OPN and A20 expression provided complementary prognostic stratification for HCC patients. Consequently, our results reveal a mechanism involving OPN ubiquitination and suggest that the OPN/A20 expression profile may provide prognostic stratification for patients after HCC resection. Considering the significance of OPN expression in HCC, our research also provides insights into potential therapeutic strategies for HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsOsteopontinTumor Necrosis Factor alpha-Induced Protein 3Cell Line, TumorCell MovementCell ProliferationFemaleHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisProteolysisUbiquitinationOsteopontinSPP1 protein, humanTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3A20OPNUbiquitination

Identifiers

PMID42848287

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