Evidence map›Paper›PMID 42848283›Full record

ArticleMedical oncology (Northwood, London, England)2026

YTHDF2 drives malignant progression in cutaneous melanoma through m⁶A-dependent HMOX1-mediated ferroptosis.

Da Gu, Yulin Sun, Jinpeng Sun, Weiting Kang, Huanmin Lou, Xiaojing Li

Abstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Da GuDepartment of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Yulin SunDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Jinpeng SunDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Weiting KangDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. kangweiting@sdfmu.edu.cn.ORCID https://orcid.org/0000-0002-5190-5817
Huanmin LouDepartment of Plastic Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, Shandong, China. 13370582901@189.cn.
Xiaojing LiDepartment of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China. yfy130377@fy.ahmu.edu.cn.

Funding

China Postdoctoral Science Foundation 2023M731483Jinan Central Hospital High-level Research Cultivation Program 202105001National Natural Science Foundation of China 82503465Shandong First Medical University (Shandong Academy of Medical Sciences) Youth Science Foundation Incubation Grant Program 202201-045Shandong Provincial Natural Science Foundation ZR2022MH269Shandong Provincial Natural Science Foundation ZR2022QH270
6 · The paper itself

Abstract

N6-methyladenosine (m6A) modification plays a critical role in eukaryotic mRNA and is significantly associated with cutaneous melanoma. This study investigated the role of the m6A-binding protein YTHDF2 in the pathogenesis of cutaneous melanoma and its potential therapeutic applications. Analyses of public databases indicated that YTHDF2 exhibited elevated expression in various cancers, including cutaneous melanoma, where its levels positively correlated with PD-L1 and negatively correlated with immune and stromal scores. Functionally, the downregulation of YTHDF2 in melanoma cells suppressed proliferation and increased the population of Annexin V/PI--positive cells, an effect that was rescued by the ferroptosis inhibitor, highlighting YTHDF2's involvement in ferroptosis regulation. YTHDF2 knockdown resulted in increased intracellular Fe

Indexed as

AdenosineFerroptosisHeme Oxygenase-1MelanomaRNA-Binding ProteinsSkin NeoplasmsAnimalsCell Line, TumorCell ProliferationCutaneous Malignant MelanomaDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceRNA MethylationAdenosineHeme Oxygenase-1HMOX1 protein, humanN-methyladenosineRNA-Binding ProteinsYTHDF2 protein, humanCutaneous MelanomaFerroptosisHMOX1M6AYTHDF2

Identifiers

PMID42848283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.