Evidence map›Paper›PMID 42848260›Full record

ArticleGenes & genomics2026

NK2.2/Vnd acts as a transcriptional activator of deadpan to maintain neuroblast identity in Drosophila embryos.

Chaekyung Ryu, Sejin Kim, Jao Lee, Dami Kim, Siuk Yoo

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Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chaekyung Ryu *Department of Life Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.
Sejin Kim *Department of Life Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.
Jao LeeDepartment of Life Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.
Dami KimDepartment of Life Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.
Siuk YooDepartment of Life Sciences, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. yoosiuk@ynu.ac.kr.ORCID http://orcid.org/0000-0002-7787-1643

Funding

Ministry of Education 2025-RISE-15-115
6 · The paper itself

Abstract

backgroundDrosophila ventral nervous system defective (vnd/NK2.2) encodes a homeodomain (HD) transcription factor essential for establishing neuroblast (NB) identity in the ventral nerve cord. However, its direct downstream targets during embryonic neurogenesis remain largely unknown.

objectiveThis study aimed to identify target genes directly regulated by Vnd and elucidate the molecular mechanisms underlying their regulation during the formation of embryonic NBs.

methodsExpression profiles and embryonic phenotypes were analyzed in either vnd

resultsBoth vnd

conclusionOur findings demonstrate that Vnd directly binds to a specific cis-regulatory motif within the dpn promoter, functioning as a transcriptional activator to maintain NB identity and architectural integrity during Drosophila embryogenesis.

Indexed as

Deadpan (dpn)Embryonic neurogenesisPrimary cell cultureTranscriptional activationVentral nervous system defective (vnd)

Identifiers

PMID42848260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.