Evidence map›Paper›PMID 42848252›Full record

ReviewMedical oncology (Northwood, London, England)2026

The impact of genetic polymorphisms in xenobiotic-metabolizing enzymes and the risk of oral cancer: a critical review.

Gabriel Carvalhal de Aguiar, Daniel Vitor de Souza, Barbara Dos Anjos Rosário, Lorrany da Silva Avanci, Antonio Silva, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabriel Carvalhal de AguiarDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.
Daniel Vitor de SouzaDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.
Barbara Dos Anjos RosárioDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.
Lorrany da Silva AvanciDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.
Antonio SilvaDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil.
Rogerio Aparecido DedivitisDepartment of Head and Neck Surgery, Faculty of Medicine, Sao Paulo University, (USP), São Paulo, SP, Brazil.
Daniel Araki RibeiroDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil. daribeiro@unifesp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) affect many individuals, where exposure to xenobiotics such as tobacco, alcohol, and betel quid is highly prevalent. Inter-individual variability plays a key role regarding genetic polymorphisms in xenobiotic‑metabolizing enzymes. In this study, we searched PubMed, Scopus and Web of Science (up to April 2026) for observational studies and meta‑analyses evaluating CYP1A1, CYP1B1, CYP2E1, GSTM1, GSTT1, GSTP1 and GSTM3 polymorphisms in OSCC and OPMDs. Twenty-one studies met the inclusion criteria. Data on exposures, genotypes and risk estimates were extracted and synthesized qualitatively. Most studies showed that GSTM1 and/or GSTT1 null genotypes are associated with increased risk of OSCC, particularly in Asian cohorts with heavy tobacco and/or betel quid exposure. CYP1A1 and CYP2E1 variants exhibited more heterogeneous results, but several studies indicated elevated risk in smokers, drinkers and betel quid users. Stronger effects consistently appeared in gene-environment interaction models. Polymorphisms in Phase I and Phase II metabolizing enzymes, especially GSTM1/GSTT1 null and selected CYP1A1/CYP2E1 variants, modulate susceptibility to OSCC in exposed individuals, supporting their potential use in risk stratification and targeted prevention strategies.

Indexed as

Mouth NeoplasmsPolymorphism, GeneticXenobioticsCarcinoma, Squamous CellGene-Environment InteractionGenetic Predisposition to DiseaseGlutathione TransferaseHumansRisk FactorsGlutathione TransferaseXenobioticsCytochrome P450 polymorphismsGene–environment interactionGlutathione S-transferase polymorphismsOral squamous cell carcinoma

Identifiers

PMID42848252

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.