Evidence map›Paper›PMID 42848250›Full record

ArticleMolecular neurobiology2026

High-Frequency Repetitive Transcranial Magnetic Stimulation Attenuates Post-Stroke Brain Fibrosis by Increasing Brain-Derived Estrogen Levels: A Dual-Tracer PET/CT Study.

Yuting Cao, Peipei Tang, Dan Feng, Hankuan He, Han Wu, Yang Liu, Jinfeng Tian, Kongzhen Hu, Yuhua Zhong

Abstract read
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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuting Cao *Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Peipei Tang *Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Dan FengDepartment of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Hankuan HeDepartment of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Han WuDepartment of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yang LiuDepartment of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Jinfeng TianDepartment of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Kongzhen HuDepartment of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. kzhu@smu.edu.cn.
Yuhua ZhongDepartment of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. zhongbinyue@163.com.

Funding

National Natural Science Foundation of China 82272032National Natural Science Foundation of China 82272585
6 · The paper itself

Abstract

Fibrotic scar formation after ischemic stroke limits neuroplasticity and functional recovery. While estradiol (E2) exerts anti-fibrotic effects, the mechanisms by which high-frequency repetitive transcranial magnetic stimulation (rTMS) promotes post-stroke recovery remain poorly understood. We investigated whether rTMS attenuates post-ischemic brain fibrosis via aromatase-dependent local E2 synthesis. Male Sprague-Dawley rats subjected to permanent middle cerebral artery occlusion received high-frequency rTMS starting post-stroke day 3. Fibrosis and metabolism were evaluated using longitudinal dual-tracer [

Indexed as

BrainEstrogensPositron Emission Tomography Computed TomographyStrokeTranscranial Magnetic StimulationAnimalsFibrosisFluorodeoxyglucose F18HumansMaleRats, Sprague-DawleyEstrogensFluorodeoxyglucose F18AromataseBrain fibrosisEstradiolIschemic strokePET/CTRepetitive transcranial magnetic stimulation

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.