ArticleMolecular biology reports2026
Regulating ferroptosis: the impact of stevia on alleviating liver damage in streptozotocin-induced diabetic rats.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes-related complications are associated with ferroptosis, an iron-dependent form of cell death characterized by lipid peroxide accumulation and disrupted redox homeostasis. This study investigated the potential protective effects of aquatic Stevia extract against liver damage and ferroptosis in streptozotocin (STZ)-induced diabetic rats.
methodsTwenty-four rats were randomly allocated to four groups (n = 6/group): (1) Control, receiving 1 ml water; (2) STZ, receiving STZ (60 mg/kg) and 1 ml water; (3) Stevia, receiving aquatic Stevia extract (400 mg/kg); and (4) Met, receiving metformin (500 mg/kg). After 28 days, serum biochemical parameters, antioxidant status, inflammatory and ferroptosis-related gene expression, TUNEL assay, and liver histopathology were evaluated.
resultsCompared with diabetic controls, Stevia significantly decreased FBS (p < 0.01), ALT (p < 0.05), AST (p < 0.01), IL-6 (p < 0.001), CRP (p < 0.0001), and MDA (p < 0.01), while it increased body weight (p < 0.05), TAC (p < 0.001), and serum GPX, SOD, and CAT (all p < 0.001). Stevia upregulated GPX4 (p < 0.05), FTH1 (p < 0.01), and SLC7 (p < 0.001), while reducing the inflammatory markers NFKβ, TNFα, and IL1β. TUNEL analysis showed reduced apoptotic cells (p < 0.01), with improved liver morphology.
conclusionThese findings suggest that aquatic Stevia extract on diabetic rats through modulation of the ferroptosis pathway, highlighting its potential therapeutic benefits in diabetes-related liver complications.
Indexed as
Identifiers
42848237What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.