ArticlePharmacological reports : PR2026
Sex-dependent and long-term effects of cisplatin on bone mineral density in juvenile mice.
Article in Pharmacological reports : PR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCisplatin is an anti-neoplastic treatment widely used to treat pediatric cancers. Negative effects of cisplatin treatment on bone mass have previously been reported; however, long-term effects of cisplatin on skeletal health and potential sex differences have largely been unexplored.
methodsFour-week-old BALB/c mice were treated with cisplatin (4 mg/kg, intraperitoneally, twice weekly for four weeks). At 13 weeks of age, we assessed structural changes in the tibiofemoral region using microcomputed tomography. We also quantified, using immunohistochemistry and confocal microscopy, the density of tartrate-resistant acid phosphatase
resultsAt 13 weeks of age, both female and male mice treated with cisplatin showed a significantly greater decrease in trabecular, but not cortical, bone mass in the tibiofemoral region than saline-treated mice. This decrease in trabecular bone mass was significantly greater in females than in males. The density of TRAcP
conclusionThese findings suggest that cisplatin induced sex-dependent and long-term complications in the skeletal system, which may partially explain the greater incidence of fractures in childhood cancer survivors.
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