Evidence map›Paper›PMID 42848126›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2026

Analysis of acrylamide in food additives via Michael addition derivatization and liquid chromatography-tandem mass spectrometry.

Shimba Kawasue, Takashi Kurohara, Koji Fujihara, Shohei Takada, Yutaka Abe, Naoki Sugimoto

Abstract read
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In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shimba KawasueNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan. skawasue@nihs.go.jp.ORCID http://orcid.org/0000-0003-4675-2083
Takashi KuroharaNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan. tks-kurohara@nihs.go.jp.ORCID http://orcid.org/0000-0003-4228-3478
Koji FujiharaNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Shohei TakadaNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.ORCID http://orcid.org/0009-0007-6460-2480
Yutaka AbeNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Naoki SugimotoNational Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.

Funding

Consumer Affairs Agency, Government of Japan 23KA1012Japan Food Chemical Research Foundation Japan Food Chemical Research Foundation
6 · The paper itself

Abstract

Acrylamide (AA) is a highly polar compound that exhibits poor retention and low selectivity in conventional reversed-phase LC-MS analyses. To establish a derivatization-based LC-MS/MS method for AA, we evaluated the potential of 5-(dimethylamino)-N-(2-sulfanylethyl)naphthalene-1-sulfonamide (DNS-SH) as an effective derivatization reagent and compared its performance with that of other representative thiol reagents. The ionization efficiency, the formation of product ions during collision-induced dissociation, and the progress of the reaction-as analyzed by LC-MS (MS/MS)-were accurately evaluated based on the molar ratios determined by

Indexed as

AcrylamideComputational studyDerivatizationLC–MS/MSMichael addition

Identifiers

PMID42848126

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.