SynthesisSports medicine - open2026
Impact of Aerobic Exercise on Endothelial Function and Other Cardiovascular Disease Markers in Health and Disease: A Systematic Review and Meta-analysis with Meta-regression of Randomized Controlled Trials.
Synthesis in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
Funding
Abstract
backgroundAerobic exercise (AE) has long been recognized as a potent stimulus for improving various cardiovascular disease (CVD)-related markers. Although several meta-analyses have focused on some of these markers, no meta-analysis or meta-regression has comprehensively evaluated the influence of multiple CVD-related markers on endothelial function, assessed by brachial-artery flow-mediated dilation (
methodsThis meta-analysis and meta-regression included randomized controlled trials investigating the effect of AE on
resultsSeventy-two studies comprising 3357 participants were included. AE significantly improved
conclusionsAE elicits robust improvements in endothelial function and a wide range of CVD-related markers. This is the first meta-analysis to integrate these outcomes through meta-regression, demonstrating that exercise induced enhancements in body composition, cardiorespiratory fitness, blood pressure and insulin regulation collectively contribute to endothelial adaptations. These findings provide new mechanistic insights into the vascular benefits of AE and reinforce its role as a potent nonpharmacological strategy for CVD prevention and vascular health optimization. The protocol was prospectively registered in the Open Science Framework online registry (DOI: https://doi.org/10.17605/OSF.IO/E4QYD ).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.