Evidence map›Paper›PMID 42848116›Full record

ArticleJournal of computer-aided molecular design2026

Computer-aided molecular engineering of novel imidazolone-chalcone conjugates as antidiabetic agent: synthesis, molecular docking, DFT study, enzyme kinetics and ADME profiling.

Tayyiaba Iqbal, Sampath Chinnam, Iftikhar Hussain, Masi A Almalki, Sobhi M Gomha, Magdi E A Zaki, Khasan Kayumov, Aftab Ahmad Khan, Rania H Taha, Faoz H Al-Atawi and 2 more

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Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tayyiaba IqbalDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan. tayyiaba.iqbal23@gmail.com.ORCID https://orcid.org/0009-0003-3517-8853
Sampath ChinnamDepartment of Chemistry, M.S. Ramaiah Institute of Technology, MSR Nagar, Bengaluru, Karnataka, 560054, India.
Iftikhar HussainDepartment of Pharmacy, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan.
Masi A AlmalkiDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia.
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.
Khasan KayumovNational University of Uzbekistan Named After Mirza Ulugbek, Tashkent, Uzbekistan.
Aftab Ahmad KhanCollege of Hydraulic and Environmental Engineering, China Three Gorges University, Yichang, 443002, China.
Rania H TahaChemistry Department, College of Science, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Faoz H Al-AtawiDepartment of Chemistry, College of Science, Majmaah University, 11952, Al Majmaah, Saudi Arabia.
Ahmad IrfanDepartment of Chemistry, College of Science, King Khalid University, P. O. Box 9004, 61413, Abha, Saudi Arabia.
Shoaib KhanDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan. shoaibkhan@aust.edu.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to identify potent drug candidates against diabetes mellitus (DM), particularly through inhibition of the key carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase. For this purpose, a series of novel imidazolone-based chalcone derivatives was synthesized through an efficient and rapid synthetic route. The synthesized analogues were initially monitored and confirmed by thin-layer chromatography (TLC). Their structural characteristics were established using

Indexed as

alpha-AmylasesChalconeGlycoside Hydrolase InhibitorsHypoglycemic AgentsImidazolesalpha-GlucosidasesComputer-Aided DesignDensity Functional TheoryHumansKineticsMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesChalconeGlycoside Hydrolase InhibitorsHypoglycemic AgentsImidazolesimidazoloneComputer-aided drug designDFT and ADMETDiabetes mellitusMD simulationMolecular dockingPharmacophore modeling

Identifiers

PMID42848116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.