Evidence map›Paper›PMID 42848088›Full record

ArticleJournal of molecular histology2026

Surfactant protein A (SP-A) alleviates acute kidney injury by reducing macrophage recruitment and M1 polarization.

Jiayun Zhang, Jinjing Guo, Jie Fu, Dahui Wang

Abstract read
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Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiayun Zhang *Department of Urology, The Affiliated Funan Hospital of Fuyang Normal University, Fuyang, Anhui, China. m15856849120@163.com.
Jinjing Guo *Fuyang Medical College, Fuyang Normal University, Fuyang, Anhui, China.
Jie FuDepartment of Urology, The Affiliated Funan Hospital of Fuyang Normal University, Fuyang, Anhui, China.
Dahui WangDepartment of Urology, The Affiliated Funan Hospital of Fuyang Normal University, Fuyang, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a severe clinical condition characterized by rapid renal function decline and intense intrarenal inflammation. Surfactant Protein A (SP-A), known for its pulmonary immunomodulatory roles, is investigated here for its therapeutic potential in AKI recovery. Using a male C57BL/6J mouse model of bilateral renal pedicle clamping, we demonstrate that an SP-A agonist significantly preserves renal function, reducing serum creatinine and urea nitrogen levels, and attenuates histopathological tissue damage. Mechanistically, SP-A activation suppresses the infiltration of CD11b

Indexed as

Acute Kidney InjuryCell PolarityMacrophagesPulmonary Surfactant-Associated Protein AAnimalsCell MovementCytokinesKidneyLipopolysaccharidesMacrophage ActivationMaleMiceMice, Inbred C57BLNF-kappa BRAW 264.7 CellsSignal TransductionCytokinesLipopolysaccharidesNF-kappa BPulmonary Surfactant-Associated Protein AAcute kidney injuryM1 polarizationMacrophageNF-κB PathwaySurfactant protein A

Identifiers

PMID42848088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.