Evidence map›Paper›PMID 42847575›Full record

ArticleJACC. Case reports2026

Rapid Native and Bioprosthetic Tricuspid Valve Degeneration in Carcinoid Heart Disease.

Lucia Trabucchi, Richiele Forgiarini, Maria I Ardid, Abraham Abdemur, Raul E Herrera, Rodolfo Arce, Tom C Nguyen, Ramon Quesada, Elliott J Elias, Nish Patel

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lucia TrabucchiMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Richiele ForgiariniMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Maria I ArdidMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Abraham AbdemurMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA. Electronic address: Abraham.Abdemur@Baptisthealth.Net.
Raul E HerreraMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Rodolfo ArceHerbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Tom C NguyenMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Ramon QuesadaMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Elliott J EliasMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
Nish PatelMiami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarcinoid heart disease (CaHD) is a severe complication of metastatic neuroendocrine tumors characterized by serotonin-mediated fibrotic degeneration of right-sided cardiac valves. CASE SUMMARY: We present 3 patients with metastatic neuroendocrine tumors complicated by severe carcinoid valvulopathy involving native and prosthetic tricuspid valves. Two patients underwent bioprosthetic tricuspid valve replacement for severe tricuspid regurgitation, including 1 patient who developed rapid recurrent prosthetic valve degeneration requiring transcatheter tricuspid valve-in-valve replacement. A third patient presented with advanced bivalvular carcinoid involvement requiring complex surgical reconstruction complicated by postoperative cardiogenic shock and death. DISCUSSION: These cases illustrate the progressive nature of serotonin-mediated valvular degeneration, challenges in prosthetic valve selection, and the importance of multidisciplinary management and close echocardiographic surveillance in CaHD. TAKE-HOME MESSAGES: Persistent serotonin exposure may result in rapid degeneration of native and bioprosthetic valves despite surgical intervention. Early recognition and multidisciplinary management are essential to optimize outcomes in CaHD.

Indexed as

bioprosthetic valve degenerationcarcinoid heart diseaseneuroendocrine tumortricuspid regurgitationvalve-in-valve replacement

Identifiers

PMID42847575
PMCPMC13669901

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