ArticleCell biochemistry and function2026
Exosomal let-7c-5p From AMI Patient Plasma Modulates Neuronal PANoptosis via ZBP1 In Vitro.
Article in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Acute myocardial infarction (AMI) significantly elevates the risk of ischemic stroke (IS), yet the molecular mechanisms linking cardiac and cerebral injury remain unclear. Emerging evidence highlights the role of circulating exosomes in mediating inter-organ communication via microRNAs (miRNAs). In this study, plasma exosomes from AMI patients were isolated at three time points (before, 2 hours after, and 24 hours after reperfusion therapy (RT)), and the exosomal let-7c-5p level was measured. The effects of plasma exosomes on neuronal SH-SY5Y cells under normoxic and oxygen-glucose deprivation (OGD) conditions were evaluated by assessing cell viability and the Z-DNA binding protein 1 (ZBP1)/PANoptosis pathway using CCK-8 assay and western blot analysis. let-7c-5p was overexpressed to clarify its role in the ZBP1/PANoptosis pathway. Exosomal let-7c-5p from AMI patients showed differences at three time points. Exosomes collected before reperfusion therapy induced the most PANoptosis under normal conditions, whereas those collected 2 hours post-reperfusion therapy had the greatest effect under OGD. These effects correlated with dynamic changes in exosomal let-7c-5p levels and the expression of ZBP1. Let-7c-5p overexpression reduced ZBP1 and PANoptotic markers, suggesting a neuroprotective role under ischemic stress. Our study suggested that the exosomal let-7c-5p/ZBP1/PANoptosis axis may contribute to AMI-related brain injury, offering potential therapeutic targets for intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.