Evidence map›Paper›PMID 42847345›Full record

ArticleEuropean journal of immunology2026

Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis.

Viola Pitkänen, Bella Lappalainen, Marja Rytkönen-Nissinen, Terhi Remes-Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna-Maija Grönlund, Miika Arvonen, Liisa Kröger, Anna-Mari Schroderus and 1 more

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Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Viola PitkänenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Bella LappalainenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Marja Rytkönen-NissinenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Terhi Remes-PakarinenDepartment of Children and Adolescents, Kuopio University Hospital, Kuopio, Finland.
Paula VähäsaloResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Milja MöttönenDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Minna-Maija GrönlundDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Miika ArvonenDepartment of Children and Adolescents, Kuopio University Hospital, Kuopio, Finland.
Liisa KrögerDepartment of Children and Adolescents, Kuopio University Hospital, Kuopio, Finland.
Anna-Mari SchroderusInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Tuure KinnunenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

Funding

Foundation for Pediatric ResearchImmuDocs Doctoral Education PilotPäivikki and Sakari Sohlberg Foundation
6 · The paper itself

Abstract

Juvenile idiopathic arthritis (JIA) is a common inflammatory rheumatic disease of childhood, yet the mechanisms driving immune activation in affected joints remain unclear. In this study, we analyzed synovial fluid (SF) immune cells from patients with JIA using two complementary methodologies, single-cell multiomics and flow cytometry. SF displayed a markedly altered immune landscape compared with blood. Both myeloid and plasmacytoid dendritic cells were enriched in SF, and SF monocytes exhibited signs of macrophage differentiation. B cells were strikingly rare in SF, and the few B cells present were predominantly CD21

Indexed as

Arthritis, JuvenileSynovial FluidAdolescentB-LymphocytesChildDendritic CellsFemaleFlow CytometryHumansKiller Cells, NaturalMacrophagesMaleautoimmunityflow cytometryinflamed jointjuvenile idiopathic arthritissingle‐cell multi‐omics

Identifiers

PMID42847345
PMCPMC13647478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.