ArticleGenome biology and evolution2026
Lateralized Gene Splicing in the Brain is Associated With Lateralized Feeding Behavior in an Asymmetrical Scale-eating Cichlid Fish.
Article in Genome biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateralized behavior ("handedness") is a trait observed across all vertebrates, including humans. As an adaptive trait involved in both intraspecific and interspecific interactions, it holds broad evolutionary significance. However, the molecular basis of its brain regulation-particularly post-transcriptional regulation-remains poorly understood. Perissodus microlepis, a textbook example in evolutionary biology and an endemic scale-eating cichlid fish from Lake Tanganyika, displays pronounced lateralized feeding behavior that is complemented by its asymmetric head, by which it bites the scales preferentially from only one side or the other side of its prey. Based on data from two previous studies, we investigated the patterns of alternative splicing-an important yet understudied regulatory mechanism-across multiple brain regions in both resting and predatory states of L-eft or the R-ight morphs of this species. We found that the telencephalon, the cognitive center of the vertebrate brain, shows enrichment in functions related to microtubule and neural development in both states. Compared to the resting state, brain regions in the predatory state exhibited more consistent functional profiles, exhibiting pronounced enrichment in the nervous system. We identified several genes whose proportion of alternatively spliced transcripts was strongly correlated with behavioral laterality, establishing a potentially causal link between alternative splicing and handedness. Our findings underscore the significant role of alternative splicing in important adaptive traits, such as lateralized behavior and present a set of candidate genes for further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.