ArticleGeburtshilfe und Frauenheilkunde2026
Clinical Performance of a Delphi Consensus and the sFlt-1/PlGF-ratio in Guiding Delivery Decisions in Early-Onset Preeclampsia Before 32 Weeks.
Article in Geburtshilfe und Frauenheilkunde, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: A recent Delphi consensus defined organ-system-based parameters intended to reflect disease severity and delivery urgency in preeclampsia (PE) ≤ 32 weeks. This study evaluates the applicability of these parameters in a real-world cohort. Methods: In a retrospective cohort of 1928 women with suspected PE, 148 presented at ≤ 32 weeks, of whom 84 (56.8%) delivered at ≤ 32 weeks. Delivery indications documented in medical records were compared with organ-based Delphi criteria, and Likert scores were calculated. The association between the Delphi Score and the risk of PE-related delivery, as well as Delphi organ-system scores, mean maximal arterial blood pressure and the sFlt-1/PlGF-ratio were examined using regression analysis. ROC analyses and likelihood ratio tests were used to assess the Delphi score, sFlt-1/PlGF-ratio, and the combination of both to predict PE-related delivery. Results: The Delphi score was associated with an increased risk of PE-related deliveries ≤ 32+0 weeks (OR 1.27 per point, 95% CI 1.12-1.45), p < 0.001) but demonstrated limited predictive accuracy (AUC 0.699 (95% CI 0.612-0.787). Adding the sFlt-1/PlGF-ratio markedly improved model performance (χ Conclusion: In this retrospective real-world cohort, the Delphi score showed limited applicability for guiding delivery decisions in PE ≤ 32 weeks. Incorporating broader hypertension thresholds and biomarkers may enhance decision-making approaches.
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