Evidence map›Paper›PMID 42847091›Full record

ArticleJournal of dermato-oncology2026

SIRT6 promotes a mesenchymal, invasive phenotype in melanoma.

Liz M Garcia-Peterson, Amelia M Lemkuil, Mary A Ndiaye, Nihal Ahmad, Gagan Chhabra

Abstract read
In one paragraph

Article in Journal of dermato-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liz M Garcia-PetersonDepartment of Dermatology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-7231-280X
Amelia M LemkuilDepartment of Dermatology, University of Wisconsin, Madison, WI, USA.ORCID 0009-0008-3208-353X
Mary A NdiayeDepartment of Dermatology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-5254-1840
Nihal AhmadDepartment of Dermatology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-4239-9887
Gagan ChhabraDepartment of Dermatology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0001-5205-7218

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
BLRD VA IK6 BX006041CSRD VA I01 CX002210NCI NIH HHS P30 CA014520NIH HHS S10 OD023526
6 · The paper itself

Abstract

Melanoma is a highly aggressive cutaneous malignancy with significant metastatic potential, posing ongoing challenges in elucidating the molecular mechanisms driving its progression. Epithelial-mesenchymal transition (EMT) is a key process that enhances cancer cell migration and invasion, facilitating metastatic dissemination. Sirtuin 6 (SIRT6), a NAD

Indexed as

EMTmelanomaphenotype switchingsirtuinSkin

Identifiers

PMID42847091
PMCPMC13645373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.