Evidence map›Paper›PMID 42846996›Full record

ArticleAutophagy reports2026

LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patients.

Quentin Frenger, Julie Lucas, Arthur Petitdemange, Luisa Path, Nadège Wadier, Sabine Depauw, Stéphane Giorgiutti, Yazhuo Gong, Hélène Merlin, Aurore Meyer and 14 more

Abstract read
In one paragraph

Article in Autophagy reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Quentin FrengerFaculty of Life Sciences, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-2057-3813
Julie LucasFaculty of Life Sciences, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0009-0003-6805-0100
Arthur PetitdemangeInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-4631-2849
Luisa PathFaculty of Life Sciences, University of Strasbourg, Strasbourg, France.
Nadège WadierInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.
Sabine DepauwInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.
Stéphane GiorgiuttiInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-4791-9618
Yazhuo GongDepartment of Rheumatology, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Hélène MerlinDepartment of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Aurore MeyerDepartment of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Mathilde HerberDepartment of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Léa JaquelDepartment of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Philippe MertzFaculty of Medicine, University of Strasbourg, Strasbourg, France.
Renaud FeltenFaculty of Medicine, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-4951-4032
Emmanuel ChatelusFaculty of Medicine, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-7360-6527
Yannick DieudonneInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0001-5132-664X
Aurélien GuffroyInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0003-0615-5305
Laurent ArnaudFaculty of Medicine, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-8077-8394
Vincent PoindronDepartment of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-3453-6976
Jacques-Eric GottenbergFaculty of Medicine, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-9469-946X
Jean SibiliaInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-1601-4795
Anne-Sophie KorganowInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-1664-6311
Thierry MartinInserm UMR_S 1109 - Immuno-Rhumatologie moléculaire, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-2776-2641
Frédéric GrosFaculty of Life Sciences, University of Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-6252-4323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy-related (ATG) proteins orchestrate canonical autophagy and related pathways, including LC3-associated phagocytosis (LAP). Autophagy and LAP play essential roles in immune homeostasis and regulation. Systemic sclerosis (SSc) is an autoimmune disease of unknown etiology characterized by progressive fibrosis affecting the skin and multiple internal organs, together with profound immune dysregulation.

Indexed as

autoimmunityAutophagyconjugation of ATG8 to single membranes (CASM)efferocytosisLC3-associated phagocytosismacrophagessystemic sclerosis

Identifiers

PMID42846996
PMCPMC13644612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.