ArticleFrontiers in veterinary science2026
Neuroimmune responses in the chicken brain during acute fowl adenovirus serotype 4 infection.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Fowl adenovirus serotype 4 (FAdV-4) causes fatal hepatitis in chickens and has a substantial impact on the poultry industry. The virus primarily targets the liver in chickens. Although viral load in the brain has been previously reported, the association of acute FAdV-4 infection with brain immune response remains poorly characterized. Therefore, this study focuses on immune alterations in the brain during acute FAdV-4 infection. Methods: Here, we investigated an increase in immune cell populations, along with the expression of barrier-related genes, to define the neuroimmune response during FAdV-4 infection. Results: Our results demonstrated that there was an alteration in the immune cell population, characterized by an increased frequencies of activated monocytes/macrophages and T cell subsets in the brain from infected chickens. Additionally, the CD44 Discussion: Together, these findings suggest acute FAdV-4 infection-associated neuroimmune alterations, mapping a distinct immunophenotypic and transcriptional landscape within the avian brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.