Evidence map›Paper›PMID 42846775›Full record

ArticleFrontiers in cardiovascular medicine2026

Genetic association of NOS3 rs1799983 variant and hypertension across multiple rural Indonesian populations: a multi-ethnic population-based study.

Bambang Dwiputra, Widyan Putra Anantawikrama, Bambang Widyantoro, Ade Meidian Ambari, Jason Phowira, Naufal Zuhdi, Sri Idaiani, Ari Winasti Satyagraha, Reza Yuridian Purwoko, Elok Ekawati and 2 more

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bambang DwiputraDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Widyan Putra AnantawikramaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Bambang WidyantoroDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Ade Meidian AmbariDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Jason PhowiraDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Naufal ZuhdiDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Sri IdaianiResearch Center for Preclinical and Clinical Medicine, National Research and Innovation Agency, Jakarta, Indonesia.
Ari Winasti SatyagrahaEijkman Research Center for Molecular Biology, National Research and Innovation Agency, Jakarta, Indonesia.
Reza Yuridian PurwokoResearch Center for Preclinical and Clinical Medicine, National Research and Innovation Agency, Jakarta, Indonesia.
Elok EkawatiDivision of Cardiovascular Research and Development, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Shoma Adhi WijayaDivision of Cardiovascular Research and Development, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Anwar SantosoDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypertension is a complex polygenic disorder where genetic variants become clinically relevant primarily when they contribute to endothelial dysfunction. While the Materials & methods: This population-based case-control study included 798 individuals with hypertension and 448 subjects with normal blood pressure from four primarily rural Indonesian regions: Papua, Pamijahan, Morotai, and Natuna. Genotyping of the Results: In the pooled population, no significant unadjusted categorical association existed between the NOS3 variant and hypertension ( Conclusions: The T allele of the

Indexed as

geneticsHypertensionNOS3 geners1799983 variantrural

Identifiers

PMID42846775
PMCPMC13643596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.