ReviewFrontiers in immunology2026
Antibody-drug conjugates in gastric cancer: from targeted cytotoxicity to immune modulation.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) remains a major cause of cancer-related mortality, and therapeutic resistance and tumor heterogeneity continue to limit durable responses in advanced disease. Antibody-drug conjugates (ADCs), which combine the target specificity of monoclonal antibodies with highly potent cytotoxic payloads, have emerged as an important component of biomarker-guided therapy. Beyond selective payload delivery, accumulating evidence indicates that ADCs can interact with antitumor immunity through Fc-mediated immune-effector functions, immunogenic tumor-cell death, enhanced antigen presentation, recruitment of effector T cells, and remodeling of the tumor immune microenvironment. In this review, we summarize the structural and pharmacological principles of ADCs and discuss established and emerging targets in GC, including HER2, CLDN18.2, HER3, GCC, TROP2, Nectin-4, EGFR, and MUC1. Particular emphasis is placed on the immunological consequences of ADC treatment and the mechanistic rationale for combining ADCs with immune checkpoint inhibitors. We further discuss tumor heterogeneity, resistance mechanisms, biomarker selection, treatment-related toxicities, and emerging combination strategies. Integrating tumor-antigen biology with immune-contextual features may enable more rational patient selection and therapeutic combinations. Collectively, next-generation ADCs may function not only as targeted cytotoxic agents but also as modulators of antitumor immunity in gastric cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.