ReviewCureus2026
Ranolazine in Chronic Stable Angina: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic stable angina (CSA) significantly impairs functional capacity and quality of life (QoL), with many patients remaining symptomatic despite standard treatment. Ranolazine, a late sodium current inhibitor, is utilized as an adjunctive antianginal therapy. This systematic review and meta-analysis evaluates its efficacy and safety in adult patients with CSA. We searched major databases through April 2025 for studies comparing ranolazine to placebo or standard therapy. Efficacy outcomes included angina burden, exercise parameters, QoL, and major adverse cardiovascular events (MACE), including myocardial infarction (MI) and revascularization. Safety was assessed via adverse event incidence. Data were synthesized using random-effects meta-analysis. Sixty-nine studies were included. Ranolazine significantly improved objective exercise measures, increasing exercise duration (mean difference {MD}, 33.1 seconds; 95% confidence interval {CI}, 27.3-38.9), time to angina onset (MD, 42.8 seconds; 95% CI, 34.2-51.5), and time to 1-mm ST depression (MD, 43.2 seconds; 95% CI, 33.8-52.6). Ranolazine was associated with a reduced risk of MI (risk ratio {RR}, 0.91; 95% CI, 0.84-0.98), coronary artery bypass grafting (CABG; RR, 0.55; 95% CI, 0.35-0.86), and any revascularization such as percutaneous coronary intervention (PCI) or CABG (RR, 0.77; 95% CI, 0.64-0.91). Adverse events were more frequent in the ranolazine group (RR, 1.45; 95% CI, 1.27-1.66) but were predominantly non-serious. Ranolazine provides robust symptomatic and functional benefits in patients with CSA. It is associated with modest reductions in MI and revascularization procedures, such as PCI or CABG. The data support ranolazine as an effective therapy for patients with CSA.
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