ArticleNano today2024
Dynamic Fractal Ice Nano-Nucleators for Cancer Cryotherapy.
Article in Nano today, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
We present cryo-responsive dynamic fractal ice nano-nucleators (DF-INNs) for cryo-cancer therapy applications. Our development of DF-INNs leverages their structural advantages, which inherently maximizes the number of active sites for heterogeneous ice nucleation. Owing to their radially attached nanocrystalline structure, DF-INNs expose an extensive array of grain boundaries. The rapid precipitation and subsequent radial attachments of nanocrystallites promote the exposure of facets with high Miller indices, intrinsically strained, five-fold twinned nanocrystals, and increasing point defects due to kinetically-limited precipitation. This unique fractal structure culminates in the elevating of freezing temperature compared to Euclidean-shaped ice nucleators. Additionally, the branched fractal structure of DF-INNs facilitates heterogenic ice formation within its nanoconfined region, leading to the production of numerous self-similar small fractal fragments. This fragmentation is primarily driven by nanoconfinement-induced delayed ice nucleation, similar to frost heaving. The shear stress can be easily relieved through grain boundary sliding within the radially stacked DF-INN, making itself prone to cryo-responsive fragmentation. Such dynamic attributes significantly enhance ice nucleating activity, presenting a powerful strategy to increase the efficacy of cryotherapy by enhancing cellular ice formation and
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Registered trials
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