Evidence map›Paper›PMID 42846606›Full record

ArticleJBMR plus2026

A novel mouse trauma model for osteonecrosis of the femoral head.

Zeynep Bal, Yukika Tanabe, Fitriana Nur Rahmawati, Man Wang, Faya Nuralda Sitompul, Ru Su, Nobuyuki Takakura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zeynep BalWorld Premier Institute Immunology Frontier Research Center, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0003-1563-5036
Yukika TanabeDepartment of Signal Transduction, Research Institute for Microbial Diseases, The University of Osaka, Suita 565-0871, Japan.
Fitriana Nur RahmawatiDepartment of Signal Transduction, Research Institute for Microbial Diseases, The University of Osaka, Suita 565-0871, Japan.
Man WangDepartment of Signal Transduction, Research Institute for Microbial Diseases, The University of Osaka, Suita 565-0871, Japan.
Faya Nuralda SitompulDepartment of Signal Transduction, Research Institute for Microbial Diseases, The University of Osaka, Suita 565-0871, Japan.
Ru SuDepartment of Signal Transduction, Research Institute for Microbial Diseases, The University of Osaka, Suita 565-0871, Japan.
Nobuyuki TakakuraWorld Premier Institute Immunology Frontier Research Center, The University of Osaka, Suita 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteonecrosis of the femoral head (ONFH) is a devastating condition characterized by the disruption of vascular supply, progressive bone degeneration, and eventual collapse of the femoral head. While corticosteroid- and alcohol-induced ONFH models are well established, a reliable trauma-induced ONFH model in mice has not been previously described. However, traumatic ONFH is commonly seen in clinical settings-such as following FN fracture, dislocation, or hip trauma-but remains poorly understood at the mechanistic level due to a lack of appropriate small-animal models. To address this gap, we established and validated a novel, reproducible trauma-induced ONFH model in C57BL/6 mice. Eight-week-old male C57BL/6 mice (

Indexed as

angiogenesisfemoral head osteonecrosishipH-type vesselsmouse modelosteonecrosistrauma-induced modelvascular dysfunctionvascularization

Identifiers

PMID42846606
PMCPMC13644813

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.