ArticleFrontiers in nutrition2026
Association between the triglyceride-high-density lipoprotein-glucose-body index and atrial fibrillation: a retrospective case-control study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance and has been associated with atrial fibrillation (AF) risk, but it does not capture adiposity. The triglyceride-high-density lipoprotein-glucose-body (TyHGB) index, which integrates lipid profile, glucose metabolism, and body mass index, may provide a more comprehensive metabolic assessment. However, evidence regarding its association with AF remains limited. Methods: This retrospective case-control study included 1,137 participants (314 non-AF controls, 414 paroxysmal AF, and 409 persistent AF). Multivariable logistic regression was performed using three hierarchical models. Restricted cubic splines were used to examine non-linear relationships. Receiver operating characteristic curves were generated to compare the predictive performance of TyHGB, TyG, and their combination. Results: Both TyHGB and TyG were independently associated with AF risk across all models (all Conclusions: TyHGB is a novel, simple, and low-cost metabolic index independently associated with AF risk, with predictive performance comparable to TyG. It may serve as a convenient complementary marker for metabolic risk assessment in clinical practice.
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