Evidence map›Paper›PMID 42846538›Full record

ArticleFundamental research2026

Targeting C3aR/STAT3 signaling attenuates neuroinflammation and reverses neurological impairment in Neuromyelitis optica.

Li Xu, Xinyi Wang, Huiming Xu, Siqi Chen, Wei Jiang, Haoyang Li, Shabbir Khan Afridi, Yuge Wang, Wenjing Luo, Hui Yang and 2 more

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Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li XuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Xinyi WangDepartment of Neurobiology, Heilongjiang Provincial Key Laboratory of Neurobiology, Basic Medical College, Harbin Medical University, Harbin 150081, China.
Huiming XuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Siqi ChenDepartment of Medical Retina and Neuro-Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Wei JiangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Haoyang LiDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Shabbir Khan AfridiFaculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK.
Yuge WangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Wenjing LuoDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Hui YangDepartment of Neurobiology, Heilongjiang Provincial Key Laboratory of Neurobiology, Basic Medical College, Harbin Medical University, Harbin 150081, China.
Changyong TangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Wei QiuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abundant evidence indicates that the interaction between astrocytes and microglia through the C3-C3a receptor (C3aR) pathway is a crucial contributor to the pathogenesis of neurodegenerative and autoimmune disorders, such as neuromyelitis optica (NMO). However, the role of C3aR in microglia in modulating inflammation related to local lesions and neurological dysfunctions in NMO remains unclear. In this study, we reveal for the first time that the expression of C3aR on microglia is positively correlated with microglial activation, proinflammatory cytokine secretion, and complement deposition, which results in the typical NMO-like lesion characterized by astrocyte injury with aquaporin 4 (AQP4) loss, demyelination, and motor neuron loss, as well as cognitive impairments, visual defects, and locomotor deficits in different models of NMO. The knockdown of C3aR or the use of a C3aR antagonist, both

Indexed as

C3aR-STAT3 pathwayMicrogliaNeuroinflammationNeurological dysfunctionNeuromyelitis optica (NMO)

Identifiers

PMID42846538
PMCPMC13644504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.