ReviewFrontiers in cell and developmental biology2026
Iron, lipid peroxidation and discogenic pain: a redox framework for ferroptosis in intervertebral disc degeneration.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The weak correlation between radiographic disc degeneration and pain intensity remains unresolved in intervertebral disc degeneration (IVDD). This Review proposes that iron-dependent lipid peroxidation and ferroptosis-associated redox signalling constitute an underrecognised link between degenerative stress and a pro-nociceptive disc microenvironment. Two linked frameworks are developed. The pro-ferroptotic niche integrates four disc-specific mechanisms: Piezo1-mediated iron influx, ferroportin suppression, ferritinophagy mediated by the cargo receptor NCOA4, and glycolysis-derived lactate upregulating the PUFA-activating enzyme ACSL4. ALOX15-coupled lipid peroxidation rests mainly on cross-disease inference. The ferroptotic pain hub proposes that resulting damage-associated signals, including the alarmin HMGB1 and 4-hydroxynonenal, may converge on NF-
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