ArticleFrontiers in medicine2026
Efficacy of a two-dimensional intervention model combining breathing training and psychological support for dyspnea management in patients with advanced cancer: a randomized controlled trial.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Dyspnea affects 50%-70% of patients with advanced cancer. Current management typically addresses physiological or psychological aspects in isolation. This trial evaluated a two-dimensional intervention targeting both breathing mechanics and psychological distress simultaneously. Methods: This four-arm randomized controlled trial enrolled 160 patients with advanced cancer and moderate-to-severe dyspnea, allocated to Control (standard care), Breathing Training (BT), Psychological Support (PS), or Combined intervention ( Results: The Combined intervention produced significantly greater VAS improvement vs. Control (-0.93 vs -0.21, Conclusions: The two-dimensional intervention demonstrates comprehensive efficacy for cancer-related dyspnea across physical and psychological domains, achieving the largest effect sizes despite additive rather than synergistic effects. Clinical trial registration: This trial was not registered in a public clinical trials registry. The absence of prospective registration is acknowledged as a limitation of the study (see Discussion).
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