ArticleFrontiers in parasitology2026
Bioaminergic signaling in parasitic flatworms: a perspective for linking GPCRs to behavior and drug discovery.
Article in Frontiers in parasitology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bioaminergic signaling regulates behaviors that are central to parasite survival, including movement, attachment, feeding, pairing, and reproduction, yet the molecular pathways linking bioamines to these phenotypes remain incompletely defined in parasitic flatworms. In this Perspective, we propose a pathway-to-phenotype framework for organizing future studies of flatworm aminergic signaling. This framework links six interconnected areas of investigation: the bioamine ligand, the receptor or transporter that detects or clears it, the downstream signaling pathway, the relevant cell type or tissue, the experimental perturbation used to test function, and the resulting parasite phenotype. Serotonin signaling through Sm5HTR in
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