ArticleReproductive medicine and biology
A Prospective Study on Clinical Utility of Preimplantation Genetic Testing for Aneuploidy and Structural Rearrangement Under Advanced Medical Care B in Japan.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the clinical utility of preimplantation genetic testing for aneuploidy and structural rearrangements (PGT-A/SR) under Advanced Medical Care B in Japan. Methods: This prospective, single-arm, multicenter benchmarking study included couples with recurrent implantation failure, recurrent pregnancy loss, or structural chromosomal rearrangements who underwent PGT-A/SR and first transfer of a category A/B embryo. The primary endpoint was ongoing pregnancy rate per transfer (oPR) at 12-13 weeks; clinical pregnancy rate (cPR) was prespecified as supportive because the registry benchmark used cPR. Outcomes were compared with age-adjusted national registry thresholds using a one-sample proportion test with a normal approximation. Results: Of 375 couples, 344 underwent PGT-A/SR and 218 reached first transfer. oPR was 48.6% versus 42.4% ( Conclusions: On a per-transfer basis, PGT-A/SR was associated with higher cPR and lower miscarriage rate, particularly in women aged ≥ 35 years. Interpretation is limited by the single-arm design and the mismatch between the study endpoint and the registry comparator. Trial Registration: This study was registered in the Japan Registry of Clinical Trials (jRCT) (jRCT1052220197).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.