Evidence map›Paper›PMID 42846172›Full record

ArticleEuropean heart journal open2026

Impact of differences in kidney function estimation by creatinine compared to cystatin C on clinical outcomes in patients with atrial fibrillation.

Philipp Krisai, Mikko Mutti, Stefanie Aeschbacher, Michael Coslovsky, Tobias Reichlin, Nicolas Rodondi, Peter Ammann, Giorgio Moschovitis, Elia Rigamonti, Giulio Conte and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02105844 (Swiss Atrial Fibrillation Cohort Study - SWISS AF), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02105844 active not recruitingnot on this map

Swiss Atrial Fibrillation Cohort Study - SWISS AF

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2014 to 2030Enrolled2,415ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Philipp KrisaiCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0002-4367-2363
Mikko MuttiCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0009-0001-9346-5311
Stefanie AeschbacherCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0001-8134-2421
Michael CoslovskyCardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.ORCID https://orcid.org/0000-0001-7678-7354
Tobias ReichlinDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 20, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0002-7197-8415
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland.ORCID https://orcid.org/0000-0001-9083-6896
Peter AmmannDepartment of Cardiology, Kantonsspital St Gallen, Rorschacher Strasse 95, 9000 St Gallen, Switzerland.ORCID https://orcid.org/0000-0002-2410-9807
Giorgio MoschovitisDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland.ORCID https://orcid.org/0000-0002-4043-8061
Elia RigamontiDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland.ORCID https://orcid.org/0000-0002-8726-6244
Giulio ConteDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland.ORCID https://orcid.org/0000-0003-2248-3456
Moa L HallerInstitute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland.ORCID https://orcid.org/0009-0006-2380-349X
Amelie StoecklinCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.
Leo H BonatiDepartment of Neurology and Stroke Center, University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0003-1163-8133
Stefan OsswaldCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0002-9240-6731
David ConenPopulation Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada.ORCID https://orcid.org/0000-0002-2459-5251
Felix MahfoudCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0002-4425-549X
Michael KühneCardiology/Electrophysiology Division, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0002-2937-3711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Differences between cystatin C-based and creatinine-based glomerular filtration rate estimations (eGFRdiff) have been associated with adverse outcomes. We aimed to investigate the prevalence of eGFRdiff and its association with clinical outcomes and brain lesions in patients with atrial fibrillation (AF). Methods and results: We analysed 3804 patients with AF enrolled in two prospective, multicentre cohort studies. The eGFRdiff was calculated by 'cystatin C-based eGFR-creatinine-based eGFR'. Patients were stratified into three groups: eGFRdiff >10, -10 to 10, and <-10 mL/min/1.73 m². Associations with high-sensitivity troponin T (hs-TnT), NT-proBNP, major adverse cardiovascular (CV) events (stroke/systemic embolism, myocardial infarction and CV death), first heart failure (HF) hospitalization, and magnetic resonance imaging (MRI)-detected brain lesions were assessed. The mean age was 71 years, 28% were female, and 49% had paroxysmal AF. An eGFRdiff of >10, -10 to 10, and <-10 mL/min/1.73 m Conclusion: A substantial proportion of patients with AF exhibit clinically relevant eGFRdiff. More negative eGFR difference was associated with elevated cardiac biomarkers, greater burden of ischaemic brain lesions, and increased risk of CV events and HF hospitalization. ClinicalTrialsgov Identifier: NCT02105844.

Indexed as

atrial fibrillationbiomarkercreatininecystatin Cglomerular filtration rate

Identifiers

PMID42846172
PMCPMC13643174

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.