Evidence map›Paper›PMID 42846146›Full record

ReviewInternational journal of cell biology2026

Exploring the Expanding Role of Nuclear Receptor LRH-1/NR5A2 in Cell Biology and Immunity.

Eleni Tsapalou, Panagiotis Michael, Maria Georgoula, Konstantinos Michail, Stamatia Papoutsopoulou, Barry J Campbell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eleni TsapalouDepartment of Biochemistry and Biotechnology School of Health Sciences University of Thessaly Biopolis Campus Larissa Greece uth.gr.ORCID https://orcid.org/0009-0008-2270-3889
Panagiotis MichaelDepartment of Molecular Biology and Genetics Democritus University of Thrace Alexandroupolis Greece duth.gr.ORCID https://orcid.org/0009-0003-6290-3141
Maria GeorgoulaDepartment of Biochemistry and Biotechnology School of Health Sciences University of Thessaly Biopolis Campus Larissa Greece uth.gr.ORCID https://orcid.org/0009-0002-6333-9485
Konstantinos MichailDepartment of Biochemistry and Biotechnology School of Health Sciences University of Thessaly Biopolis Campus Larissa Greece uth.gr.ORCID https://orcid.org/0009-0003-3385-4707
Stamatia PapoutsopoulouDepartment of Biochemistry and Biotechnology School of Health Sciences University of Thessaly Biopolis Campus Larissa Greece uth.gr.ORCID https://orcid.org/0000-0001-6665-8508
Barry J CampbellDepartment of Infection Biology and Microbiomes Institute of Infection Veterinary and Ecological Sciences University of Liverpool Liverpool UK liv.ac.uk.ORCID https://orcid.org/0000-0002-7407-012X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LRH-1/NR5A2 is a member of the NR5A subfamily of nuclear receptors, acting as a crucial transcription factor involved in diverse biological processes. Although LRH-1 has been extensively studied in vitro and in vivo, in relation to its role in embryonic development and differentiation and in adult tissue processes, such as cholesterol, glucose, and ethanol metabolism, current knowledge about its function in immunity is very limited. This review, therefore, presents the most recent knowledge regarding

Indexed as

epitheliumimmune cellsliver receptor homolog-1nuclear receptor subfamily 5 group A member 2orphan receptortranscription factor

Identifiers

PMID42846146
PMCPMC13643060

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.