Evidence map›Paper›PMID 42846126›Full record

ReviewStem cells international2026

Beyond the Cell: Stem Cell-Derived Exosomes as Next-Generation Tools in Regenerative Therapy.

Hazem A El-Kady, Majdeldin E Abdelgilil, Hagar W Mandour, Rahaf Altartoor, Ziad Mustafa Abd El-Wahab, Sarah Alosman, Soha M Abdelzaher, Ibrahim M Fangary, Yasmine Hosny

Abstract readReview
In one paragraph

Review in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hazem A El-KadyApplied Biotechnology Program Faculty of Science Ain Shams University Cairo Egypt asu.edu.eg.ORCID https://orcid.org/0009-0007-8927-425X
Majdeldin E AbdelgililApplied Biotechnology Program Faculty of Science Ain Shams University Cairo Egypt asu.edu.eg.ORCID https://orcid.org/0009-0002-7378-5083
Hagar W MandourApplied Biotechnology Program Faculty of Science Ain Shams University Cairo Egypt asu.edu.eg.
Rahaf AltartoorDepartment of Molecular Biology and Genetics Istanbul Medeniyet University Istanbul Türkiye medeniyet.edu.tr.ORCID https://orcid.org/0009-0007-8232-8382
Ziad Mustafa Abd El-WahabApplied Biotechnology Program Faculty of Science Ain Shams University Cairo Egypt asu.edu.eg.
Sarah AlosmanDepartment of Molecular Biology and Genetics Istanbul Medeniyet University Istanbul Türkiye medeniyet.edu.tr.ORCID https://orcid.org/0009-0007-4558-247X
Soha M AbdelzaherApplied Biotechnology Program Faculty of Science Ain Shams University Cairo Egypt asu.edu.eg.
Ibrahim M FangaryApplied Biotechnology Program Faculty of Science Ain Shams University Cairo Egypt asu.edu.eg.
Yasmine HosnyBiotechnology Department Faculty of Science King Salman International University South Sinai Egypt ksiu.edu.eg.ORCID https://orcid.org/0000-0002-7913-9819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes derived from stem cells have gained significant interest in recent years due to their considerable promise as a cell-free therapy in drug delivery and regenerative medicine. Their therapeutic appeal lies in their immune-modulating properties, along with a lower risk of immune response or tumor formation compared to whole cell-based therapies. It has been highlighted that exosomes can be engineered to deliver therapeutic molecules such as RNAs, proteins, and drugs to specific cells, tissues, and organs, making them a promising tool for targeted therapies. This review summarizes the sources of exosomes from different types of stem cells, covering the components of their molecular cargos from different types of RNAs, proteins, growth factors, and other molecules. The focus is on the different advanced methods used to isolate and characterize the exosomes. Exosomes have many therapeutic applications related to cancer, cardiovascular diseases, neurodegenerative disease, wound healing, bone repair, and renal and hepatic injuries.

Indexed as

characterizationexosomesisolationmolecular cargoregenerative medicinestem cellstherapeutic applications

Identifiers

PMID42846126
PMCPMC13643360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.