ArticleFrontiers in neurology2026
Free triiodothyronine in intracranial aneurysms: a sex-specific association with unruptured disease and a non-thyroidal illness signal after rupture.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Thyroid dysfunction has been implicated in neurovascular pathologies, but its role in intracranial aneurysm formation and rupture is uncertain. Materials and. Methods: This is a retrospective single-centre case-control study of patients with unruptured (UIA) or ruptured intracranial aneurysms (RIA) and aneurysm-free controls. Low free triiodothyronine (fT3) was defined as below 3.5 pmol/L. Multivariable logistic regression was adjusted for age, sex, hypertension, alcohol abuse, and smoking. Results: The cohort comprised 1,100 patients (60.0% female), including UIA ( Discussion and conclusion: Reduced fT3 in RIA may partly reflect impaired peripheral conversion after haemorrhage, but low fT3 was also independently associated with aneurysm presence in females. Low fT3 may be a candidate endocrine marker associated with aneurysm presence. Whether thyroid optimisation influences aneurysm development remains to be tested in prospective studies.
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