ArticleFrontiers in neurology2026
Association between admission blood urea nitrogen and clinical outcomes in patients with large ischemic stroke undergoing endovascular treatment.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to investigate the association between admission blood urea nitrogen (BUN) and clinical outcomes in patients with large ischemic stroke undergoing endovascular treatment (EVT). Methods: This study was a subgroup analysis of a prospective, multicenter cohort study. 472 patients with large ischemic stroke undergoing EVT from the original database were included. Patients were stratified into three groups based on admission BUN levels. The primary effectiveness outcome was modified Rankin Scale (mRS) score 0-3 at 90 days. Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH) within 48 h. Results: A total of 472 patients were included and stratified into three groups: Tertile 1 group (≤5.00 mmol/L), Tertile 2 group (5.01-6.80 mmol/L), and Tertile 3 group (>6.80 mmol/L). Compared with patients in BUN Tertile 1 group, patients in BUN Tertile 3 had significantly lower odds of achieving a favorable outcome (adjusted odds ratio [aOR] 0.54, 95% CI 0.31-0.95, Conclusion: In patients with large ischemic stroke undergoing EVT, an elevated admission BUN (>6.80 mmol/L) was associated with a lower likelihood of favorable functional outcome at 90 days.
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