Evidence map›Paper›PMID 42845916›Full record

ArticleFrontiers in neurology2026

Exploratory associations between APOE-ε

Marziye Eshghi, Panying Rong, Mehrdad Dadgostar, Hyunmin Shin, Brian D Richburg, Nelson V Barnett, David H Salat, Steven E Arnold, Jordan R Green

Abstract read
In one paragraph

Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marziye Eshghi *Department of Communication Sciences & Disorders, MGH Institute of Health Professions, Charlestown, MA, United States.
Panying Rong *Department of Speech-Language-Hearing: Science and Disorders, University of Kansas, Lawrence, KS, United States.
Mehrdad DadgostarDepartment of Communication Sciences & Disorders, MGH Institute of Health Professions, Charlestown, MA, United States.
Hyunmin ShinDepartment of Communication Sciences & Disorders, MGH Institute of Health Professions, Charlestown, MA, United States.
Brian D RichburgDepartment of Communication Sciences & Disorders, MGH Institute of Health Professions, Charlestown, MA, United States.
Nelson V BarnettDepartment of Communication Sciences & Disorders, MGH Institute of Health Professions, Charlestown, MA, United States.
David H SalatAthinoula A. Martinos Center for Biomedical Imaging, Harvard-MIT Health Sciences and Technology School, Massachusetts General Hospital, Charlestown, MA, United States.
Steven E ArnoldAthinoula A. Martinos Center for Biomedical Imaging, Harvard-MIT Health Sciences and Technology School, Massachusetts General Hospital, Charlestown, MA, United States.
Jordan R GreenDepartment of Communication Sciences & Disorders, MGH Institute of Health Professions, Charlestown, MA, United States.

Funding

Validating novel sleep sensors and devices in older adults with Alzheimer's diseaseP30AG073107 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Benjamin M. Marlin · 2021 to 2026
$32.0M
Social Connectedness in People with Amyotrophic Lateral Sclerosis: The Impact of Dysarthria, Immobility, and Psychosocial FactorsR01DC021446 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI Kathryn Patricia Connaghan, JORDAN R GREEN · 2024 to 2026
$1.8M
Early Biomarkers of Alzheimer's Disease: Using Speech Markers to Detect Mild Cognitive ImpairmentK23DC019179 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI ESHGHI, MARZIYE · 2021 to 2025
$1.1M
Prolonging Functional Speech in Persons with Amyotrophic Lateral Sclerosis: A Real-Time Virtual Vocal TractK24DC016312 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI GREEN, JORDAN R · 2017 to 2021
$949k
Microvascular hemodynamics and speech function in adults at risk for Alzheimer's diseaseR15AG101712 · NIA · MGH INSTITUTE OF HEALTH PROFESSIONS · PI Marziye Eshghi · 2026 to 2026
$624k
NIA NIH HHS P30 AG073107NIA NIH HHS R15 AG101712NIDCD NIH HHS K23 DC019179NIDCD NIH HHS K24 DC016312NIDCD NIH HHS R01 DC021446
6 · The paper itself

Abstract

Introduction: The APOE-ε Methods: Forty-two cognitively intact adults (16 APOE-ε Results: APOE-ε Discussion: These findings suggest that speech-based neuromuscular changes may serve as exploratory candidate indicators of neuromuscular vulnerability associated with APOE-ε

Indexed as

Apolipoprotein E4Facial MusclesSpeechAgedCognitionCross-Sectional StudiesElectromyographyFemaleHeterozygoteHumansMaleMiddle AgedApolipoprotein E4Alzheimer's diseaseAPOE-ε4 genotypeelectromyographygenetic risk factormotor unit synchronizationneuromuscular functionspeech biomarkers

Identifiers

PMID42845916
PMCPMC13642023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.