ArticleFrontiers in immunology2026
Physiological upregulation of RAG1 expression compromises the survival of CD4
Abani Kanta Naik, Javid P Mohammed, Rebecca A Glynn, Craig H Bassing, Michael S Krangel
Abstract read
In one paragraphArticle in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Abani Kanta NaikDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, United States.
Javid P MohammedDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, United States.
Rebecca A GlynnDepartment of Pathology and Laboratory Medicine, Children's Hospital of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Craig H BassingDepartment of Pathology and Laboratory Medicine, Children's Hospital of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Michael S KrangelDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, United States.
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8MChromatin regulation of TCR locus V(D)J recombinationR35GM136284 · NIGMS · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2020 to 2024
$2.4MElucidating Mechanisms of RAG Endonuclease Mediated Feedback Inhibition of V(D)J RecombinationR01AI172163 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSING, CRAIG H · 2022 to 2025
$2.2MExploring a Functional Role of Chromosome Loop Extrusion Direction on Regulating Genome BiologyR21AI174545 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSING, CRAIG H · 2023 to 2024
$490kNCI NIH HHS P30 CA014236NIAID NIH HHS R01 AI172163NIAID NIH HHS R21 AI174545NIGMS NIH HHS R35 GM136284
6 · The paper itselfAbstract
Thymocytes upregulate expression of recombination activating genes (RAGs) upon developmental transition from the CD4
Indexed as
Homeodomain ProteinsThymocytesAnimalsCell SurvivalDNA-Binding ProteinsMiceMice, Inbred C57BLMice, KnockoutUp-RegulationV(D)J RecombinationDNA-Binding ProteinsHomeodomain ProteinsRAG-1 proteincell survivalrecombination activating gene 1T cellthymusV(D)J recombination
Identifiers
PMID42845884
PMCPMC13642656
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