Evidence map›Paper›PMID 42845849›Full record

ArticleNature sensors2026

Base gap switches as transcriptional regulators and their applications as biosensors.

Yukina Partington, Beatrice Dalla Via, Fabrice Abgottspon, Isaure de Geyer, Piet Cools, Andrew J deMello, Daniel A Richards

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yukina PartingtonInstitute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland.ORCID 0009-0009-2772-0482
Beatrice Dalla ViaInstitute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland.ORCID 0009-0009-1741-537X
Fabrice AbgottsponInstitute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland.
Isaure de GeyerInstitute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland.
Piet CoolsDepartment of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.ORCID 0000-0003-2980-5307
Andrew J deMelloInstitute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland.ORCID 0000-0003-1943-1356
Daniel A RichardsInstitute for Chemical and Bioengineering, ETH Zurich, Zürich, Switzerland.ORCID 0000-0001-8827-9170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcriptional and translational regulators ('switches') function as biosensors by controlling how gene circuits respond to specific stimuli. However, contemporary switches suffer from spontaneous activation or off-target responses, limiting sensitivity and specificity. Here we introduce base gap switches, a class of programmable transcriptional regulators that are selectively activated by DNA. Base gap switches are simple to design and install, provide tight control of gene expression and exhibit high specificity and orthogonality. They can discriminate single-nucleotide mismatches and integrate with nucleic acid amplification methods. Using base gap switches, we developed an assay for

Indexed as

Assay systemsDiagnosis

Identifiers

PMID42845849
PMCPMC13642041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.