Evidence map›Paper›PMID 42845753›Full record

ArticleResearch square2026

Brain metabolic resilience conferred by the APOE3 Christchurch variant in autosomal dominant Alzheimer's disease and across the adult lifespan.

Yakeel Quiroz, Catarina Tristão-Pereira, Vincent Malotaux, Yesica Zuluaga, Claudia Muñoz, George Silva, Bing He, Diana Alzate, Yamile Bocanegra, Alejandro Guerrero and 7 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yakeel QuirozMassachusetts General Hospital, Harvard Medical School.ORCID 0000-0001-9714-8244
Catarina Tristão-PereiraBoston University.
Vincent MalotauxBoston University.
Yesica ZuluagaGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Claudia MuñozGrupo de Neurociencias de Antioquia.
George SilvaBoston University.
Bing HeBoston University.
Diana AlzateGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Yamile BocanegraUniversidad de Antioquia.
Alejandro GuerreroUniversidad de Antioquia.ORCID 0000-0003-3952-1412
Laura SernaUniversidad de Antioquia.
Carolina OspinaUniversidad de Antioquia.ORCID 0000-0002-8666-7273
Monica VidalHospital Pablo Tobón Uribe.
Sergio AlvarezHospital Pablo Tobón Uribe.
Rafael Posada-DuqueUniversidad de Antioquia.
Joseph Arboleda-VelasquezSchepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, USA.ORCID 0000-0002-3192-9117
David AguillonUniversidad de Antioquia.ORCID 0000-0003-2283-536X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Identifiers

PMID42845753
PMCPMC13640913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.