Evidence map›Paper›PMID 42845699›Full record

ArticleResearch square2026

Adrenomedullary Organoids Derived from Neural Crest and Schwann Cell Precursors.

Hsueh-Fu Wu, Jessica McAlpine, Christina James, Tripti Saini, Piyush Padhi, Samantha D Baxley, Casey L Stewart, Dong Eun Seo, Mo-Fan Huang, Heidi Ulrichs and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hsueh-Fu WuUniversity of Georgia.
Jessica McAlpineUniversity of Georgia.
Christina JamesUniversity of Georgia.
Tripti SainiUniversity of Georgia.
Piyush PadhiUniversity of Georgia.
Samantha D BaxleyUniversity of Georgia.
Casey L StewartUniversity of Georgia.
Dong Eun SeoUniversity of Georgia.
Mo-Fan HuangThe University of Texas Health Science Center at Houston.
Heidi UlrichsUniversity of Georgia.
Jennifer ArtUniversity of Georgia.
Fabio R SantoriUniversity of Georgia.
Anumantha G KanthasamyUniversity of Georgia.
Dung-Fang LeeThe University of Texas Health Science Center at Houston.
Natalia B IvanovaUniversity of Georgia.
Oshri AvrahamUniversity of Georgia.
Nadja ZeltnerUniversity of Georgia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adrenal gland, essential for survival, contains the medulla and cortex. Chromaffin cells (ChrCs) in the adrenal medulla control the fight-or-flight response by releasing catecholamines like epinephrine and norepinephrine. Recent findings reveal that ChrCs originate from two progenitors: 20% from developmentally early, neural crest-derived sympathoadrenal progenitors (SAPs) and 80% from the later Schwann cell precursors (SCPs). We generated functional adrenomedullary organoids from human pluripotent stem cells (hPSCs) via both pathways and in mixed (20% SAP, 80% SCP-derived) cultures. When implanted into chicken embryos, the organoids migrated and integrated into the adrenal gland anlagen.

Indexed as

adrenal glandschromaffin cellshuman pluripotent stem cellsorganoidsSchwann cell precursorsympathoadrenal progenitor

Identifiers

PMID42845699
PMCPMC13640924

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.